COVID-19-associated acute disseminated encephalomyelitis (ADEM)

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Acute disseminated encephalomyelitis (ADEM) is characterized by its rapid progression with variable symptoms and severity in adults and children. Multiple therapeutic options have been proposed, but solid evidence is yet to be gathered. We describe an adult man with a fulminant form of ADEM unresponsive to numerous treatment modalities.

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INTRODUCTION Unvaccinated patients with history of splenectomy are prone to fulminant courses of Streptococcus pneumoniae-associated bacterial meningitis. Besides direct brain damage those patients may additionally suffer from parainfectious syndromes, notably vasculitis and acute disseminated encephalomyelitis (ADEM). Differentiation and treatment of these immunological reactions is challengin...

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ژورنال

عنوان ژورنال: Journal of Neurology

سال: 2020

ISSN: 0340-5354,1432-1459

DOI: 10.1007/s00415-020-09951-9